NIH Complement Animal Research in Experimentation NAMs Reduction to Practice Challenge
Department of Health and Human Services - National Institutes of Health
Who can apply
To be eligible to win a prize under this Challenge, a Participant (whether participating as a Team or Entity) — a.
About this opportunity
Recent technological advances have set the stage for a renewed focus on human-based solutions called new approach methodologies (NAMs) that can complement, and in some cases replace, animal models in research and regulatory testing. These NAMs generally span advanced cell-tissue-organoid ( in vitro ), computational modeling ( in silico ), and cell-free biochemical analysis ( in chemico ) techniques, with each type of NAM offering different advantages. A combination and integration of multiple NAMs elements into a synergistic approach that augments gaps and/or deficiencies in individual NAMs approaches is a “combinatorial NAM” and could ultimately allow for improved predictions of human clinical response. Although many combinatorial NAMs are still early in development, not validated and sta...