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Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)

National Institutes of Health

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Posted
Dec 17, 2025
Amount
$400,000
Closes
Nov 5, 2028 (in 842 days)

Classification and identifiers

Solicitation number
PAR-25-362
Assistance listing (CFDA)
93.865

Amount

$400,000

Who can apply

Tribal organizationsLocal governmentsNonprofitsTribal governmentsNonprofits (non-501c3)State governments

Local government agencies, Nonprofits, including small and volunteer-run organizations, and State government agencies can all apply here. Check the eligibility details below to see if your organization fits.

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

About this opportunity

The purpose of this Notice of Funding Opportunity (NOFO) is tofurther elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART).This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity.

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