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Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)

National Institutes of Health

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Posted
Dec 17, 2025
Amount
$400,000
Closes
Nov 5, 2028 (in 752 days)

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Classification and identifiers

Solicitation number
PAR-25-362
Assistance listing (CFDA)
93.865

Amount

$400,000

Who can apply

Tribal organizationsLocal governmentsNonprofitsTribal governmentsNonprofits (non-501c3)State governments

Local government agencies, Nonprofits, and State government agencies can all apply here. Check the eligibility details below to see if your organization fits.

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

About this opportunity

The purpose of this Notice of Funding Opportunity (NOFO) is tofurther elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART).This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity.

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