Recurrent Glioblastomas
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Who can apply
8(a) Sole Source. 8AN
About this opportunity
The goal of this clinical trial is to evaluate progression-free and overall survival in participants with recurrent glioblastoma receiving LMP744 compared to historic controls. We will also directly compare molecular and metabolic profiles of tissue, CSF, and plasma pre- and postexposure to LMP744 to determine pharmacologic responses to the drug in this patient population. We will also correlate the pre- and post-exposure molecular and metabolic profiles with clinical response and outcome, to determine which molecular and metabolic features are predictive of drug response. The latter information will be critical for the design of phase III clinical trials involving LMP744. Finally, we will evaluate the safety of LMP744 in patients with recurrent glioblastoma through continuous, objective m...