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Exploratory Clinical Neuroscience Research on Substance Use Disorders (R61/R33 Clinical Trial Optional)

National Institutes of Health

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Posted
Mar 16, 2026
Closes
Jun 16, 2028 (in 609 days)

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Classification and identifiers

Solicitation number
PAR-27-053
Assistance listing (CFDA)
93.279

Amount

Amount not listed here. Check the official program.

Who can apply

Local governmentsTribal organizationsNonprofits (non-501c3)NonprofitsState governmentsSchool districts

Local government agencies, Nonprofits, and State government agencies can all apply here. Check the eligibility details below to see if your organization fits.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

About this opportunity

This Notice of Funding Opportunity (NOFO) uses a R61/R33 Phased Innovation Award mechanism to support clinical research applications that are exploratory and developmental in nature and focus on understanding the neurobiological mechanisms underlying SUD, including fundamental brain function relevant to substance use. This NOFO is particularly designed to support exploratory/developmental projects requiring budgets that would exceed that allowed for the R21 mechanism (Neuroscience Research on Drug Abuse (R21 Clinical Trial Optional)

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