Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
National Institutes of Health
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- Posted
- Oct 23, 2025
- Amount
- $1,500,000
- Closes
- Dec 14, 2026 (in 65 days)
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Classification and identifiers
- Solicitation number
- RFA-HG-27-009
- Assistance listing (CFDA)
- 93.172
Amount
$1,500,000
Who can apply
Nonprofits, including small and volunteer-run organizations, Small businesses, and Public colleges and universities can all apply here. Check the eligibility details below to see if your organization fits.
Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply; Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply; Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
About this opportunity
The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, centers funded through this initiative will propose a research framework to investigate whether interactions, with effects beyond additive, are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions. The rationale for this research is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding ...