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Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)

National Institutes of Health

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Posted
Mar 11, 2026
Closes
Oct 11, 2029 (in 1092 days)

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Classification and identifiers

Solicitation number
PAR-28-014
Assistance listing (CFDA)
93.113

Amount

Amount not listed here. Check the official program.

Who can apply

County governmentsHousing authoritiesSchool districtsNonprofits (non-501c3)Public universitiesTribal governments

Public colleges and universities can apply here. Check the eligibility details below to see if your organization fits.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

About this opportunity

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should address one or more of the following: i) what modifiable exposures are driving the increase in the incidence of non-hereditary EOCs, and how do these factors vary by patient demographics? (ii) what biological mechanisms and host responses underly the increase in EOCs? and (iii) how can those at increased risk for dev...

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