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Coming Soon·Opens soon·Synced from source July 6, 2026

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

National Institutes of Health

View official posting
Posted
May 20, 2026
Amount
$212,004 - $2,725,311
Closes
No deadline published by the funder
Last verified
Jul 6, 2026

At a glance

This funding opportunity is offered by National Institutes of Health. Awards range from $212,004 to $2,725,311.

Classification and identifiers

Solicitation number
PAR-28-019
Assistance listing (CFDA)
93.351

Amount

$212,004 - $2,725,311

Who can apply

NonprofitsState governmentsTribal organizationsNonprofits (non-501c3)County governmentsHousing authorities

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

About this opportunity

This NOFO is issued during a period of accelerating development, validation, and adoption of human new approach methodologies (NAMs). Accordingly, it has two integrated priorities for NIH-funded HIV/AIDS research: (1) implementation of a NAMs-enabled stewardship framework, including optional HIV-relevant human in vitro testing support and pilot benchmarking activities, to reduce or replace specific pathogen free (SPF) in vivo model use where scientifically appropriate without compromising rigor, reproducibility, or translational relevance; and (2) support for high-quality SPF colony resources for studies in which well-characterized in vivo models remain scientifically necessary. Under the NAMs-enabled component, required elements include: (1) integration of a NAMs triage and consultation s...

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