NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
National Institutes of Health
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- Posted
- Oct 23, 2025
- Closes
- Apr 5, 2029 (in 980 days)
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Classification and identifiers
- Solicitation number
- PA-27-101
- Assistance listing (CFDA)
- 93.853
Amount
Amount not published by the funder
Who can apply
Small businesses can apply here. Check the eligibility details below to see if your organization fits.
Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international...
About this opportunity
The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).
Related opportunities
- NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)National Institutes of HealthCloses Apr 2027
- NIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)National Institutes of HealthCloses Apr 2027
- Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)National Institutes of HealthCloses Nov 2028
- Limited Competition: Small Grant Program for NHLBI K01/K08/K23/K25 Recipients (R03 Clinical Trial Optional)National Institutes of HealthCloses Nov 2028Up to $85K
- Limited Competition: Small Grant Program for Mentored Research Career Development Award Recipients (R03) (Clinical Trials Not Allowed)National Institutes of HealthCloses Jul 2029