Protein ENGineering (PENG)
DEPT OF DEFENSE
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- Posted
- Aug 8, 2026
- Closes
- Oct 19, 2026 (in 27 days)
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At a glance
This is a government contract opportunity posted by DEPT OF DEFENSE in the research and development in biotechnology (except nanobiotechnology) category. The deadline is October 19, 2026, 27 days from now.
Classification and identifiers
- Industry (NAICS)
- Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- Product or service (PSC)
- National Defense R&D Services; Department of Defense - Military; Applied Research (AC12)
- Solicitation number
- DARPA-PS-26-129
- Contracting office
- DEF ADVANCED RESEARCH PROJECTS AGCY
Who can apply
About this opportunity
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological archite...