Nanobody against NPR-C for growth disorder
HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Place of performance: Bethesda, MD
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- Posted
- Aug 19, 2026
- Closes
- Aug 28, 2026 (in 9 days)
At a glance
This is a government contract opportunity posted by HEALTH AND HUMAN SERVICES, DEPARTMENT OF in the research and development in biotechnology (except nanobiotechnology) category. The deadline is August 28, 2026, 10 days from now. Work is performed in Bethesda, MD. This solicitation carries a Small Business Set Aside - Total set-aside.
Classification and identifiers
- Industry (NAICS)
- Research and Development in Biotechnology (except Nanobiotechnology) (541714)
- Product or service (PSC)
- Other Professional Services (R499)
- Solicitation number
- 75N98026Q01031
- Contracting office
- NATIONAL INSTITUTES OF HEALTH OLAO
- Set-aside
- Small Business Set Aside - Total
Who can apply
Small businesses can apply here. Check the eligibility details below to see if your organization fits.
Small Business Set Aside - Total
About this opportunity
See attached Word document. Project Title: Nanobody against NPR-C for growth disorder 1. Project Overview 1.1 Background We sought to develop nanobodies (VHH) against human NPR-C with high affinity and specificity for future clinical use. These nanobodies could potentially be further developed into therapeutics for treatment of growth disorders such as achondroplasia. 1.2 Main Objectives - generation of antigens needed for immunization - immunization of Alpaca/Ilama with target antigens generated - generation of immunized phage/yeast library and in vitro screening using the library - alternatively, single B-cell screening and sequencing instead of phage/yeast library generation/screening. - downstream functional confirmation of VHH nanobodies binding to target antigens - generation of fina...