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Advancing Real-World Effectiveness Evidence for Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (UM1 Clinical Trial Required)

National Institutes of Health

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Posted
Sep 16, 2026
Closes
Jun 10, 2027 (in 209 days)

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Classification and identifiers

Solicitation number
RFA-MH-27-150
Assistance listing (CFDA)
93.24R

Amount

Amount not listed here. Check the official program.

Who can apply

Private universitiesLocal governmentsFor-profitsCounty governmentsSmall businessHousing authorities

Private colleges and universities, Local government agencies, and Small businesses can all apply here. Check the eligibility details below to see if your organization fits.

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations…

About this opportunity

The National Institute of Mental Health (NIMH) intends to publish a Notice of Funding Opportunity (NOFO) to support the development of a research network to study rapid-acting psychotropic interventional drugs (RAPIDs), such as ketamine, esketamine, psilocybin, and other emerging treatments for serious mental illnesses. Preliminary studies suggest that RAPIDs can produce clinically meaningful improvements in mental health outcomes, in some cases following a single dose. However, important questions remain regarding their effectiveness, safety, durability of benefit, and implementation in routine clinical practice. As these interventions move toward broader use, rigorous real-world evidence is needed to identify how RAPIDs can be delivered safely, effectively, and sustainably across diverse...

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