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OpenDue September 25, 2028·Updated June 14, 2026

Avant Garde/Avenir award for Investigators conducting high risk/high reward research on HIV and Substance Use (or Substance Use Disorders)

National Institutes of Health

Who can apply

County governmentsSchool districtsSpecial districtsState governmentsTribal organizationsNonprofits+8 more

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

About this opportunity

The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.

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