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NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

National Institutes of Health

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Posted: Jan 8, 2026
Closes: Sep 3, 2026 (in 21 days)

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Classification and identifiers

Solicitation number: RFA-RM-27-003
Assistance listing (CFDA): 93.310

Amount

Amount not published by the funder

Who can apply

Private universitiesNonprofitsHousing authoritiesCounty governmentsPublic universitiesState governments

Private colleges and universities, Nonprofits, including small and volunteer-run organizations, Public colleges and universities, and State government agencies can all apply here. Check the eligibility details below to see if your organization fits.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

About this opportunity

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program ...