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Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

National Institutes of Health

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Posted: Dec 17, 2025
Amount: $300,000 - $5,000,000
Closes: Jul 1, 2028 (in 690 days)

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Classification and identifiers

Solicitation number: PAR-27-022
Assistance listing (CFDA): 93.351

Amount

$300,000 - $5,000,000

Who can apply

Public universitiesNonprofitsNonprofits (non-501c3)State governmentsTribal organizationsPrivate universities

Public colleges and universities, Nonprofits, including small and volunteer-run organizations, State government agencies, and Private colleges and universities can all apply here. Check the eligibility details below to see if your organization fits.

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

About this opportunity

This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and reproducible measurements, and encourage collaborative research and benefit broad research communities...